Facile two-step synthesis of 3-substituted indazoles using diazo(trimethylsilyl)methylmagnesium bromide.
نویسندگان
چکیده
Diazo(trimethylsilyl)methylmagnesium bromide readily reacted with various ketones and aldehydes to give the corresponding 2-diazo-(2-trimethylsilyl)ethanols. These were efficiently converted to indazoles bearing hydroxymethyl units at the 3-position by intermolecular [3 + 2] cycloaddition with benzynes.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 7 13 شماره
صفحات -
تاریخ انتشار 2009